Xiang-Ping Chu, M.D., Ph.D.

Assistant Professor
M3-417
Office: 816-235-2248
Fax: 816-235-6517

Education:

Fudan University Shanghai Medical College,
Ph.D. (Physiology, 1999)

Fudan University Shanghai Medical College,
MS (Physiology 1996)

Jiangsu University School of Medicine,
MD (Clinical Medicine, 1989)

Biography

Xiang-Ping Chu received his MD from Jiangsu University School of Medicine (Former Zhenjiang Medical College), Zhenjiang, China in 1989 and his PhD from Fudan University Shanghai Medical College (Former Shanghai Medical University), Shanghai, China in 1999. He was initially a Postdoctorate Research Fellow then progressed to Research Associate, Senior Research Associate and Assistant Scientist at Robert S. Dow Neurobiology Laboratories, Legacy Health System in Portland, OR beginning in 2000. He joined the UMKC SOM in 2008 as an Assistant Professor of Basic Medical Science (Neuroscience) and holds a second appointment in the Department of Anesthesiology. His research programs are supported by American Heart Association and University of Missouri Research Board.

Research Interest

One of my research interests is to understand the functional role of ion channels in ischemic brain injury. Brain ischemia induces various biochemical changes, which can activate various ion channels, including Acid-Sensing Ion Channels (ASICs). During hypoxia/ischemia, increased anerobic glycolysis due to the lack of blood and oxygen supply leads to lactic acid accumulation, causing a reduction in pH, and acidosis. For many years, acidosis has been known to play an important role in the pathology of neuronal injury. However, the cellular and molecular mechanisms underlying acidosis-induced injury remain elusive. Recently we have demonstrated that activation of newly described ASICs contribute to neuronal injury, particularly those containing the ASIC1a subunit. My aim is to explore the potential mechanisms by which ASIC's are involved in the pathogenesis of ischemic brain injury, particularly the extent to which they might be modulated/regulated by endogenous molecules (e.g. glucose and zinc).

ASICs localize to synapses and it is thought that protons released from synaptic vesicles activate ASICs during neurotransmission. I am also interested in studying the functional role of ASICs in the brain and the interaction between ASICs and other ion channels/receptors (for example, glutamate receptors, dopamine receptors et al.,) during physiological or pathological conditions such as drug abuse. We want to determine whether ASICs play any rols in the pathogenesis of drug abuse or interact with other receptors in the brain in response to psychostimulants.

Mentoring Area

I am interested in mentoring students who have interests in neurological diseases such as drug abuse and ischemic brain injury using a combination of patch-clamp recording, fluorescence-imaging, gene transfection and knockdown, cell injury assay and behavior measurement techniques.

Recent Publications

Jiang Q, Papasian CJ, Wang JQ, Xiong ZG and Chu XP. Inhibitory regulation of acid-sensing ion channel 3 by zinc. Neuroscience. 169: 574-583, 2010.

*Mao LM, *Wang W, *Chu XP,d Zhang GC, Liu XY, Yang YJ, Haines M, Papasian CJ, Fibuch EE, Buch S, Chen JG, Wang JQ Stability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine. Nat Neurosci. 12: 602-610, 2009. *These authors contributed equally.

Jiang Q, Li MH, Papasian CJ, Branigan D, Xiong ZG, Wang JQ, Chu XP. Characterization of acid-sensing ion channels in medium spiny neurons of mouse striatum. Neuroscience . 162: 55-66, 2009.

Zhang GC, Mao LM, Wang JQ, Chu XP. MCP-induced protein Upregulation of acid-sensing ion channel 1 protein expression by chronic administration of cocaine in the mouse striatum in vivo. Neurosci Lett. 459:119-122, 2009.

Jiang J, Li MH, Inoue K, Chu XP, Seeds J, and Xiong ZG. TRPM7-like current in human head and neck carcinoma cells: role in cell proliferation. Cancer Res.,67:10929-10938, 2007.

Hey J, Chu XP, Seeds J, Simon RP, Xiong ZG. Extracellular zinc protects against acidosis-induced injury of cells expressing Ca2+-permeable acid-sensing ion channels. Stroke, 38:670-3, 2007.

Xiong ZG, Chu XP, and Simon RP. Acid-sensing ion channels - novel therapeutic targets for ischemic brain injury. Front Biosci. 12:1376-1386, 2007.

Liu X, Chu XP, Mao L, Wang M, Lan H, Li MH, Zhang G, Parelkar NK, Haines M, Neve KA, Liu F, Xiong ZG, and Wang JQ. Modulation of D2R/NR2B interactions in response to cocaine. Neuron, 52, 897-909, 2006.

Wang WZ, *Chu XP, *Li MH, Seeds J, Simon RP and Xiong ZG. Modulation of acid-sensing ion channel currents, acid-induced increase of intracellular Ca2+, and acidosis-mediated neuronal injury by intracellular pH. J. Biol. Chem., 281: 29369-29378, 2006. *These authors contributed equally

Chu XP, Close N, Saugstad JA, and Xiong ZG. ASIC1a-specific modulation of acid-sensing ion channels in mouse cortical neurons by redox reagents. J. Neurosci., 26:5329-5339,2006.

Xiong ZG, Chu XP, and Simon RP. Acid-sensing ion channels and ischemic brain injury (invited review). J Membr Biol. 209:59-68, 2006.

Xiong ZG, *Chu XP, *Zhu XM, Minami M, Hey J, Wemmie JA, Price M, Welsh MJ, and Simon RP. Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell. 118: 687-698, 2004. *These authors contributed equally.

Chu XP, Wemmie JA, Wang WZ, Zhu XM, Saugstad JA, Price MP, Simon RP, Xiong ZG. Subunit-dependent High-Affinity Zinc Inhibition of Acid-Sensing Ion Channels. J. Neurosci., 24: 8678-8689, 2004

Chu XP, Zhu XM, Wei WL, Li GH, Simon RP, MacDonald JF, and Xiong ZG. Acidosis decreases low Ca2+-induced neuronal excitation by inhibiting the activity of calcium-sensing cation channels. J. Physiol. 550: 385-399, 2003

Stenzel-Poore MP, Stevens SL, Xiong ZG, Lessov NS, Harrington CA, Mori M, Meller R, Tobar E, Rosenzweig HL, Shaw TE, Chu XP and Simon RP. Ischemic preconditioning in the brain reprograms the genetic response to cerebral ischemia and mimics neuroprotective strategies found in hibernation. Lancet. 362:1028-1037, 2003

Meller R, Schindler CK, Chu XP, Xiong ZG, Cameron JA, Simon RP and Henshall D. Seizure-like activity leads to the release of BAD from 14-3-3 protein and cell death in hippocampal neurons in vitro. Cell Death & Diffe.10: 539 - 547, 2003

Chu XP, Miesch J, Johnson M, Root L, Zhu XM, Simon RP and Xiong ZG. Proton-gated channels in PC12 cells. J. Neurophysiol. 87: 2555-2561, 2002.