Charles W. Van Way III, M.D.

Professor of surgery

Sosland/Missouri Endowed Chair of Trauma Research

Director UMKC Shock Trauma Research Center.
charles.vanway@tmcmed.org

The UMKC Shock Trauma Research Center is engaged in research to develop new treatment strategies to reduce the amount of cell death that occurs following shock.  Besides studies in shock, the research programs of the Center include basic studies to understand the molecular events that allow cells of the immune system to “recognize” the presence of microbes and microbial products, and to communicate that information to white blood cells

Dr. Van Way’s activities have centered around hemorrhagic shock, and to exploring the basic mechanisms of cell injury during hemorrhagic shock and resuscitation, and to identify changes which produce long-term damage.   In the past several years, his research team has carried out basic and clinical studies of the genomic response to shock and injury, and has developed several potential therapeutic agents for the treatment of hemorrhagic shock.  Currently, his team is exploring the mechanisms by which cells adjust to the low-oxygen environments which characterize low perfusion states such as septic and hemorrhagic shock. 

Selected Publications:

Chang CG, Van Way CW, 3rd, Dhar A, Helling T, Jr., Hahn Y. The use of insulin and glucose during resuscitation from hemorrhagic shock increases hepatic ATP. J Surg Res. 2000;92(2):171-6.

Dhar A, Kujath S, Van Way CW, 3rd. Glutamine administration during total parenteral nutrition protects liver adenosine nucleotides during and after subsequent hemorrhagic shock. JPEN J Parenter Enteral Nutr. 2003;27(4):246-51.

Qureshi N, Vogel SN, Van Way C, 3rd, Papasian CJ, Qureshi AA, Morrison DC. The proteasome: a central regulator of inflammation and macrophage function. Immunol Res. 2005;31(3):243-60.

Yang R, Martin-Hawver L, Woodall C, Thomas A, Qureshi N, Morrison D, et al. Administration of glutamine after hemorrhagic shock restores cellular energy, reduces cell apoptosis and damage, and increases survival. JPEN J Parenter Enteral Nutr. 2007;31(2):94-100.

Yang R, Tan X, Kenney RJ, Jr., Thomas A, Landis M, Qureshi N, et al. Hemorrhagic shock in the rat: comparison of carotid and femoral cannulation. J Surg Res. 2008;144(1):124-6.

Yang R, Tan X, Thomas AM, Shen J, Qureshi N, Morrison DC, et al. Crocetin inhibits mRNA expression for tumor necrosis factor-alpha, interleukin-1beta, and inducible nitric oxide synthase in hemorrhagic shock. JPEN J Parenter Enteral Nutr. 2006;30(4):297-301.

Yang R, Tan X, Thomas AM, Steppacher R, Qureshi N, Morrison DC, et al. Alanine-glutamine dipeptide (AGD) inhibits expression of inflammation-related genes in hemorrhagic shock. JPEN J Parenter Enteral Nutr. 2007;31(1):32-6.

Yang R, Tibbs BM, Chang B, Nguyen C, Woodall C, Steppacher R, et al. Effect of DHEA on the hemodynamic response to resuscitation in a porcine model of hemorrhagic shock. J Trauma. 2006;61(6):1343-9.